In recent decades, two emergent phenomena have jointly transformed the nature and pursuit of entrepreneurship across industries and sectors: open innovation and platformization. Open innovation involves a shift toward more open and distributed models of innovation, while platformization refers to the increasing importance of digital platforms as a venue for value creation and capture. Together, open innovation and platforms have created numerous opportunities for entrepreneurs and their firms—from serving as inputs for innovation for established firms to participating as complementors on existing platforms. While these entrepreneurial opportunities (and conditions) have manifested themselves in rich and varied ways, our understanding of these new forms of entrepreneurship has lagged behind. In this essay, and in this special issue, our objective is to bring a sharper focus on the important research issues and questions that frame open innovation, platforms, and entrepreneurship.